Summary and Info
An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.
More About the Author
Alamannia or Alemannia was the territory inhabited by the Germanic Alemanni after they broke through the Roman limes in 213. The Alemanni expanded from the Main basin during the 3rd century, raiding the Roman provinces and settling on the left bank of the Rhine from the 4th century.
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