Summary and Info
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.*Written to provide a "hands-on" approach for readers*Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings*Step-by-step guide to memorize and draw lipid structures*Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique
More About the Author
Jacques Santini (born 25 April 1952 in Delle, France) is a former football player and manager. He played for Saint-Étienne during the 1970s, and reached the European Cup final with them in 1976. He has coached the French national team - winning the 2003 FIFA Confederations Cup and reaching the quarter-finals of Euro 2004 - and clubs including Olympique Lyonnais.
Review and Comments
Rate the Book
Brain Lipids in Synaptic Function and Neurological Disease: Clues to Innovative Therapeutic Strategies for Brain Disorders 0 out of 5 stars based on 0 ratings.